موکودنتول

 

اطلاعات عمومی

شرکت دانش بنیان داروسازی خُرّمان به همت متخصصان توانمند خود با توجه به نیاز جامعه و با هدف کاهش بار بیماری های عفونی حلق و دهان و عوارض ناشی از آن و به موازات آن کاهش بار مقاومت دارویی اقدام به طراحی و ساخت مخاط چسب موکودنتول بر پایه آخرین دانش روز و تحقیقات کاربردی نموده است. موکودنتول داروی ضدعفونی کننده و ضد التهاب حلق و دهان بویژه لوزه می باشد. این دارو باعث درمان سرما خوردگی ها شده و مانع افزایش میکروارگانیسم های فرصت طلب و پاتوژن ها بخصوص بعد از وقوع عفونت های ویروسی می شود.
نام تجاری: موکودنتول
نام ژنریک: کارواکرول3 درصد
دسته دارویی: فرآورده طبیعی
اثرات دارویی: ضدعفونی کننده، ضد التهاب، ضد گلودرد،بهبود تنگی نفس
موارد مصرف: مهار التهاب و عفونت حلق و دهان.
موارد ویژه مصرف: بهبود و کاهش علائم بالینی عفونت های میکروبی
موارد منع مصرف: در افراد حساس به ترکیبات فنولی مصرف نشود.
مصرف در دوران شیردهی و بارداری: بلامانع است.
تداخل دارویی: در افرادی که داروهای تیروئیدی مصرف می کنند با احتیاط مصرف شود.
طریقه مصرف:
1- به طول یک بند انگشت از مخاط چسب بین لب و لثه بالایی (وستیبول) قرار دهند.
2- برای درمان عفونت های حلقی هر 4 بار در روز و مخصوصا قبل از خواب مصرف شود.
عوارض دارویی: در افرادی که التهاب معده دارند باعث احساس ضعف می گردد. بهتر است پس از خوردن غذا دارو مصرف گردد.


General Information

Khorraman Pharmaceutical Knowledge based complex with the help of its capable specialists, according to the needs of the community and with the aim of reducing the burden of infectious diseases of the oropharynx and its complications and in parallel reducing the burden of drug resistance, designed and manufactured MucoDentol adhesive mucosa paste based on the latest Up-to-date knowledge and applied research. MucoDentol is an antiseptic and anti-inflammatory drug for the oropharynx and to relieve tonsillitis. This drug treats colds and prevents the growth of opportunistic microorganisms and pathogens, especially after the occurrence of viral infections.
Brand Name: MucoDenol
Generic name: Carvacrol 3%
Pharmaceutical category: Natural product
Drug effects: Disinfectant, Anti-inflammatory, Anti-sore throat and Improve shortness of breath.
Indications: Improve and reduce the clinical signs of microbial infections
Special uses: Colds and Flu, oral inflammation caused by osteomatitis, gingivitis, periodontitis and pests.
Contraindications: Do not use in people sensitive to phenolic compounds.
Use in lactation and pregnancy: Unrestricted.
Drug Interactions: Use with caution in people taking thyroid medications.
How to use:
1-Place a piece of adhesive mucus paste between the lips and upper gums (vestibule) along the length of a finger.
2-Use every 3 hours for 12 hours to treat throat infections.
Drug side effects: In people with gastritis, they feel weak. It is best to take the medicine after eating.


MucoDentol® Special Information

A mucous adhesive paste formula for preventing and healing clinical symptoms of Covid-19 disease.

Of the four genera of carnivorous (CoV) identified so far (α, β, γ and δ), the α & β types are more pathogenic to human.  Belonging the β genera of CoVs, severe acute respiratory syndrome (SARS), SARS-CoV and Middle East Respiratory Syndrome (MERS) have already caused worldwide epidemics in the last two decades. SRS-COV-2 is transmitted from person to person by air droplet and enter throw to body from eyes, nose and mouth cavity. The inhaled virus SARS-CoV-2 likely binds to epithelial cells in the nasal cavity and starts replicating. Of note, SARS-CoV-2 is capable of active replication in the upper respiratory tissues, as demonstrated by successful live virus isolation from throat swabs and detection of viral sub genomic messenger RNA (sgRNA) in cells of upper respiratory tract. Tropism of the upper respiratory tissue probably explains continuous pharyngeal shedding of the virus and a more efficient transmission of SARS-CoV-2 than SARS-CoV when symptoms are still minimal and restricted to the upper respiratory tract. Later in the disease course, Covid-19 resembles SARS in terms of viral replication in the lower respiratory tract, and generates secondary viremia, followed by extensive attack against target organs that express ACE2, such as heart, kidney, gastrointestinal tract and vast distal vasculature. Eventually, SARS-CoV-2 affects the gastrointestinal and respiratory system. The common symptoms of hospitalized of Covid-19 patients are fever, fatigue, cough, dyspnea, myalgia, and normal or decreased leukocyte counts and sometimes with GI sings. According to the previously studies, ARDS associated with cytokine storm which these are main high level of production of inflammatory factors such as IL-2, IL-7, IL-6, IL1β and TNF-α. Also increased inflammatory factors has been shown to be the primary reason for death in Covid-19 patients. According to the latest WHO reports many components such as ethanol 75%, Ammonium Quaternaries, formaldehyde, acetone, H2O210%, phenol 2% and phenolic component can use as surface disinfectant and most effective compounds for prevention of SRS-COV-2 virus. All of these components are toxic. In the other hand Carvacrol Know as a phenolic component that use as disinfected on oral and nasal cavity. Therefore, it is necessary to extensively study of the potential of phenol-based drugs such as herbal phenolic component. Many clinical studied has been prove that carvacrol is effective as antioxidant, antibacterial, antifungal, antiviral and anti-inflammatory. antioxidant and anti-inflammatory activity of carvacrol related to the presence of the hydroxyl (OH) group has been confirmed. Hence, it can inhibit the growth or reduce the number of pathogenic fungi or bacteria especially oral pathogen such as E. coli, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus (MRSA), S. mutans, S.sanguis, S.salivarius, S.sobrinus, E. faecalis, Candida albicans, C. dubliniensis, C.glabrata, C. tropicalis, C.krusei etc.. Also, Carvacrol can inhibit or reduce viral disease such as human rotavirus, acyclovir-resistant herpes simplex virus type 1, human respiratory syncytial virus, the pandemic H1N1 virus and human norovirus. Carvacrol displays as a good anti-inflammatory property and act as pro inflammatory mediators’ reduction, such as IL-1β, TNF-α, IL-2, and IL-6; while increasing the level of the anti-inflammatory cytokine, IL-10. Also, carvacrol can inhibit both of the cyclooxygenase (COX) enzymes COX-1 and COX-2 that synthesize proteinoids. Saturejia khuzistanica Jamzad is belong to the Lamiaceae an endemic plant that widely distributed in the southern of Iran and has been used as analgesic and antiseptic. The level of essential oil component show that Carvacrol is a main factor in the extracted essential oil with 93% value.  Carvacrol is the effective Matter of Mucoadhesive slow release paste (Mucodentol®). This continues release drug can controlling the microorganism count in oropharynx. Thus, during the viral infections Mucodentol® can prevents the secondary infections and side effect of them. Mucodentol® was used as anti-inflammatory, antibacterial, anti fungal and even antiviral in Oral infections in world. During six months in 2020 in three clinical study 1130 patients and peoples that exposed to SARS-COV-2 (200 confirmed patients, 600 people that exposed to Covid-19 and 330 hospital personal) were used Mucodentol® to reduce clinical symptom and prevent of Covid-19. The results of three study shows Mucodentol® can reduction clinical symptom and mortality rate in Covid-19 patients and reduced the incidence in people that exposed of SARS-COV-2 (P<0.05) Also, in people who use Mucodentol® if infect with this virus showed a mild form of the disease.


Co-Infection Mechanism of Action

Viral respiratory infections are very common and they are frequently eliminated from the body without any detrimental consequences. Secondary serious bacterial infection has been an apprehension expressed by health care providers, and this fear has been exacerbated in the era of Covid-19(18). Like the SARS and influenza pandemics, SARS-COV-2 have been a large number of cases coinfected with other viruses, fungi, and bacteria, some of which originate from the oral cavity. Capnocytophaga, Veillonella, and other oral opportunistic pathogens(19). Numerous studies show that the virus that causes Covid-19 uses oropharynx bacteria as carriers to cross the mucus to interaction with angiotensin-converting enzyme 2 (ACE2)(20). COVID-19 has been shown to bind to ACE2 via the S protein on its surface. Risk factors such as poor oral hygiene, cough, increased inhalation under normal or abnormal conditions, and mechanical ventilation provide a pathway for oral microorganisms to enter the lower respiratory tract and thus cause respiratory disease. During infection, the S protein is cleaved into subunits, S1 and S2. S1 contains the receptor binding domain (RBD) which allows corona-viruses to directly bind to the peptidase domain (PD) of ACE2. S2 then likely plays a role in membrane fusion. There are many studies that show that bacteria along with viruses are aggravating clinical symptoms in infected patients with covid-19(21). Studies have shown that death and disease severity are higher in people with poor oral health(oral bacterial diseases) and also the acidity of the enzyme IL-1,IL-6 and TNFα is much higher. According to the published manuscripts viruses cannot cause all clinical symptoms alone and maybe secondary bacterial infections can also be the cause(22).

عفونتهای تنفسی ویروسی بسیار رایج بوده و اغلب بدون ایجاد عارضه ی جدی توسط پاسخ ایمنی از بین می روند. عفونت های ثانویه ی ایجاد شده توسط باکتری ها هنگام ابتلا به بیماری های ویروسی از جمله 19-Covid باعث بروز خطر و نگرانی می شوند(18). مانندبیماری سارس و انفلوانزا در 2-SARS-COV نیزعفونت های ثانویه ی ایجاد شده توسط قارچ ها باکتری ها و ویروس ها که برخی از آنها از فلور طبیعی دهان مانند کاپنوسایتوفاگا، ویلونلا و سایر پاتوژن های فرصت طلب نشائت گرفته اند (19). مطالعات بیشماری نشان می دهد عامل ویروسی ایجاد کننده ی بیماری 19-Covid  از باکتریهای oropharynx به عنوان حامل برای عبور از مخاط و رسیدن به گیرنده های (ACE2) استفاده می کند. ویروس 19-Covid از طریق پروتئین S موجود در سطح خود به گیرنده های ACE2 متصل می شود. عوامل خطرزا از جمله ضعف در بهداشت دهان و دندان ، سرفه ، افزایش استنشاق در شرایط عادی یا غیر طبیعی و تهویه مکانیکی مسیری را برای ورود میکروارگانیسم های دهان به دستگاه تنفسی تحتانی ایجاد می کند و در نتیجه باعث بروز بیماری های تنفسی می شود. در طی عفونت، پروتئین S به زیر واحد ها، S1 و S2 شکسته می شود که زیرواحد S1 حاوی دومین اتصال به گیرنده (RBD) است که به کورونا ویروس اجازه می دهد به ACE2 متصل شود. احتمالا در ادامه دومین S2 در الحاق غشائی نقش دارد. مطالعات بسیاری وجود دارد که نشان می دهد باکتری ها به همراه ویروس ها باعث تشدید علائم بالینی در بیماران آلوده به کووید 19 می شوند (21). مطالعات نشان داده است که بروز فرم حاد بیماری و مرگ و میر در افرادی که بهداشت دهان و دندان پایینی دارند بیشتر از افراد عادی است. همچنین میزان تولید 1-IL,6-IL, در TNFα افرادی که در فاز حاد بیماری هستند بیشتر است. با توجه به مطالعات انجام شده ویروس ها به تنهایی نمی توانند تمام علائم بالینی را ایجاد کنند و ممکن است بخش اعظمی از بیماری به علت عفونت های ثانویه ی باکتریایی باشد (22).